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This series of fact sheets uses data collected by several agencies within the U.S. Department of Health and Human Services to illustrate cross-cutting issues with respect to families with substance use or mental health conditions, including the health and well-being of their children, and their likelihood of child welfare system involvement. The fact sheets were produced by the HHS Office of the Assistant Secretary for Planning and Evaluation in cooperation with the Department’s Behavioral Health Coordinating Committee, Subcommittee on Children and Youth.